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Pujari, Rohini
- Effect of Chlorophytum borivilianum on Fluoxetine Induced Sexual Dysfunction in Female Rats
Authors
1 AISSMS College of Pharmacy, Kennedy Road, Nr. RTO, Pune-411001, Maharashtra, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 130-133Abstract
Treatment with selective serotonin reuptake inhibitors (SSRI's) has been shown to cause reduced libido in women. A large body of evidence suggests that serotonin may influence sexual behavior in estradiol + progesterone primed, ovariectomized female rats. In the present study, the effect of 2 weeks of fluoxetine administration (10 mg/kg daily) and coadministration of fluoxetine (same dose) and hydroalcoholic extract of Chlorophytum borivilianum (CB) (100, 300 and 500 mg/kg daily) on copulatory behavior in hormone primed ovariectomized rats was investigated. Fluoxetine significantly reduced various proceptive and receptive behaviors of female rats as compared to normal rats. In contrast, these behavioral parameters were significantly increased by co administration of various doses of CB with fluoxetine as compared to fluoxetine treated rats. The results point towards the potential role and probable use of CB in females with antidepressant induced reduced libido.Keywords
Chlorophytum borivilianum, Fluoxetine, Libido, Ovariectomized, Proceptive, Receptive.References
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- Analgesic Activity of Roots of Holostemma annulare
Authors
1 Department of Pharmacognosy, Modern College of Pharmacy (For Ladies), Borhadewadi, Dehu-Alandi Road, Tal: Haveli, At Post: Moshi, Pune: 412105 Maharashtra, IN
2 Department of Pharmacognosy, Modern College of Pharmacy (For Ladies), Pune, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 2 (2011), Pagination: 77-80Abstract
In the traditional system of medicines in India, different parts of the plant Holostemma annulare (Roxb) K. Schum (HA) have been traditionally claimed to have medicinal properties. Of this plant 34 medicinal preparations are used. The ischolar_mains of the Holostemma annulare (Roxb) K. Schum have been reported to possess anti inflammatory, anti-spasmodic and anti-diabetic activity without noticable toxicity. The present study has been undertaken in order to evaluate the analgesic activity of alcoholic, aqueous and benzene extract of ischolar_mains of plant Holostemma annulare (Roxb) K. Schum using acetic acid induced writhing test.
The two doses of 300mg/kg and 600mg/kg of body weight were prepared by dissolving in water. A minimum four animals were used for each group including control, standard group receiving drug Diclofenac sodium intraperitoneally and test groups receiving different extracts of Holostemma annulare(Roxb) K. Schum ischolar_mains at doses 300mg/kg and 600mg/kg orally. It was concluded that the aqueous extract of dose 300 mg/body wt. and 600mg/body wt. has shown a significant analgesic activity. Alcoholic and Benzene extract of ischolar_mains were devoid of any analgesic activity at the dose level of 300mg/body wt., but showed a significant analgesic activity at the dose of 600mg/body wt.
In this study the results indicated that the ischolar_mains of the plant Holostemma annulare (Roxb) K. Schum possesses a significant analgesic activity.
Keywords
Holostemma annulare (roxb) K. Schum, Analgesic Activity, Acetic Acid Induced Writhing, Pain.References
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